The Hotel del Santuario is located just a few steps away from the archaeological area of the city. It is nearby the Paolo Orso Museum as well as the historical center of the city. The Hotel del Santuario is located at Via del Santuario 1 in Siracusa, Sicily. Guests can reach the nearby beach by shuttle bus or rental cars.

There are 73 rooms for renting at the Hotel del Santuario. Guests can look forward to air conditioning, private bathrooms, color satellite TVs and direct dial phones. Special provisions can be made for non-smokers and disabled individuals.

The Hotel del Santuario is a three-star hotel. The onsite restaurant at this hotel serves Mediterranean cuisine and even vegetarian dishes. The restaurant is called The Five Palms. There are also business amenities including meeting rooms (that can seat up to 150 people) and banqueting rooms for larger events. There is also new equipment for conferencing and seminar-hosting. Parking spots are free and small animals are accepted.